Dynamic observation”the levels of slCAM-1ard sVCAM-1 in the patients with acute ischemic stroke
Background Adhesion molecules play a role in the ischemic injury. It has been shown that there were changes in the patients with ischemic stroke. Objective To approach the serum level of sICAM-I and sVCAM-i in patients with acute ischemic stroke. Methods sICAM-1 and sVCAM-i were measured by enzyme-lined imunosorbent assay and were serially detemined(within 6 hours and at first. third seventh day) in 16 patients with acute ischemic stroke. Results The result showed the serum sICAM-1 in patient with acute ischemic stroke was higher within 6 hours” (558. 8±174. 8) ng/ml”. at first day ” (655. 1±89.4) ng/ml”and third day” (571.4±104. 4) ng/ml” than in the controls” (435. 3±86.6) ng/ml” (P＜0.05), especially within the first day. sVCAM-I was higher within 6 hours” (930.5.±181.7) mg/ml”、 at first day”(1174. 9±179.1)ng/ml”、 third day”( 1215.4±187.4)mg/mi” and seventh day ”(988.5 ± 148. 8) ng/ml” than in the controls ” (704.2:± 125.8) ng/ml ” (P＜0. 05), especially wi thin the first and third day. There was no significant correlation betwsen sICAM、 sVCAMt-1 levels and the extent of neurological deficits. (P＞0.05). Conclusions Serum level of sICAM-I and sVCAM-1 were elevated in acute ischemic stroke and this changes were correlated with the time after stroke
ischemic stroke、neurological deficits、Adhesion molecules
8
R3 ;R2
2005-07-07（万方平台首次上网日期，不代表论文的发表时间）
共1页
73
