Antileukocyte therapy of cerebral ischemic stroke in MCAO model in rats
OBJECTIVE To Study protecting effect of antileukocytic drugs on cerebrol ischemic injury. BACKGROUND The purposes of prcsent study aimed at comparing the protecting effect of some antileukocytic drugs: chloroquine, Colchieine, Cyclophosphamid (CTX) ,Cyclosporin A, Multiglycoside tripteygil against cerebral ischemic injury in MCAO models in the rats. METHODS 130 SD rats with MCAO model randomly divided into one control group and 10 treatment groups. The observation items were as follows: (1) The infarction volume. (2) Brain edema. (3) Histopathoiogical evaluation. (4) The count of neurons and microglia cells in the infarction area. (5) Neurological dysfunction score. (6) The determination of serum lL-1 β and TNF- α levels. RESULTS Antileukocytic drugs can decrease the volume of infarction, brain edema, inflammatory reaction and neuron death of ischemic injury, the low dose of chloroquine plus colchicine plus CTX had better effects, and prolonged therapeutic time windows. DISCUSSION The accumulation of infiammatory cell and cytoking release from them can promote and increase neuron death in infarction area. CONCLUSION Antileukocytic drugs are of protecting effect on ischemic neuron in MCAO model in rats.
determination of、time windows
8
X50;TN3
2005-07-07（万方平台首次上网日期，不代表论文的发表时间）
共1页
67
