The study of ministellite region polymorphisms at 3” end of apollpoprotein B gene in atherosclerotic cerebral infarction
Objective Atheroselerotic cerebral infarction ACI) as agradually progresive atherosclerotic disorder has been thought be a hetero-ground and multictor of environment There are in different epidemiologic state. The relationship of ministellite region polymorphisms at 3′-end of apolipoprotein B gene in Chinese ACI and normal healthy controls were observed. Method The 3′ hyprevariabieministellite polymorphism of apolipoprotein B gene were examined by polymerase chain reaction technique in 84 patients with ACI and 107 age-matched Chinese bealthy controls.The targeted ministellite region were amplified rapidly and accurately, and than identified. Results The frequency distribution of apolipoprotion B 3”ministellite region alleles were in monomold peaks at 37,39 repeat uints in both group,and the big number repeat units(MSRB) is higher in ACI than normal controls.The homozygote genotype of the big number repeat units alleles had a relationship to the high level of apolipoprotein and LDL.There were same tandency in ACI and controls. Conclusion The possibility that there apolipoprotein B 3′ gene ministellite region alleles polymorphism increase the susceptibility to atheroscierosis by means other than by altering lipoprotein levels deserves further consideration
apolipoprotein B、polymerase chain reaction、frequency distribution
8
R1 ;P7
2005-07-07（万方平台首次上网日期，不代表论文的发表时间）
共1页
65
