The molacular mechanism of ACE gene in acute cerebro-vascullar discasc
”Objective” Our research is aimed to study a possible involvement of angiotension converting enzyine (ACE) gene types and hypertension upon the molecular mechanism of clinic ACVD ”Method” Using a polymerize chain reaction (PCR), a DNA fragment of intone 16 of ACE gene was studied in 203 patients with ACVD (including 87 cases of CH and 116 cases of Al) and 51 control samples ”Rrsult” (l) The frequency of the ACE allele polymorphism jsn”t similcantly different between ACVD, CO and Al patients. (2)There is no significant difference in the ACE gene types and ACE gene allele frequency among CH、 Al and the controls. (3) There are no significant difference between history of hypertension and the incidence of CH and Al. However, patients with hypertension and ACE DD allele shoed more significant Al incidence than those with hypertension and ACE Ⅱ allele. ”Conclusion” We didn” t find any correlation between the polymorphism of the ACE gene and ACVD. Neither the history of hypertension nor polymorphism of ACE gene was a risk factor of ACVD. We didn”t find a correlation between Al and hypertension with ACE gene polymorphism. Our study suggests that ACE gene polymorphism combined with hypcnension is a possible molecular mechanism underlying Al.
molecular mechanism、gene polymorphism、allele frequency、control samples、DNA fragment、risk factor
8
R3 ;R73
2005-07-07(万方平台首次上网日期,不代表论文的发表时间)
共1页
61