Clinical Study on Evolutionary Stroke Treated by Defibrase
Objective Evolutionary stroke is one common and important subgroup of acute ischemic stroke with nerve damage symptoms evolutionarily heaving. There is not effective methods clinically to stop its development. This article aims to study the feasibility and effectiveness of Defibrase therapy on evolutionary stroke through observing curative effect of evolutionary stroke treated by defibrase therapy and analyze and compare with that of treated by routine medicine. Methods Select 52 evolutionary stroke cases 8 hours to 5 days after stroke and divide them into treatment group(28 cases):treated by 250ml saline intravenous transfusion with 10u Defibrase,once per day,after 3 successive days switch to routine treatmcnt, and control group(24 cases):receive routine treatment. Both groups have not found significant difference in age and severity through X2 inspection,and are comparable both in case history and complication accumulation.The curative effect is evaluated 10 days and 20 days after treatment respectively.Results 10 days after treatment, in treatment group total efficiency is 63%,in control group that is 36%;20 days after treatment,in treatment group total efficiency is 82% and that in control group is 53%.Both have significant difference(P＜0.01).No untoward effect such as hemorrhage occurs to both groups.Discussion and Conclutions In general speaking.within 6 hours after ischmic stroke is the optimum time to conduct thrombus-dissolution,but for evolutionary stroke the situation is still developing within several hours and even several days after stroke,that is to say thrombus is still developing or ischemia half dark band is changing to irreversible .Therefore evolutionary stroke itself is the indication of needing thrombus dissolution.Volume urokinase thrombus-dissolving therapy is easy to superven serious complication such as intracrainial hemorrhage. Insertion treatment is not matured enough limited to equipment,infarct position and curative effect. Defibrase is prepared sololy from serine protease which is extracted from viper venom through modem bio-engineering methods. It can promotes tPA to release from endothediocyte so as to achieve rapid and specific thrombus-dissolution. The study result reveals that Defibrase is an effective,safe medicine to cure evolutionary stroke
curative effect、total efficiency、effective methods、serine protease、case history、the optimum
8
R74;R47
2005-07-07（万方平台首次上网日期，不代表论文的发表时间）
共1页
60
