国家自然科学基金81100824;上海市教育委员会科研创新项目12YZ044;上海交通大学医工交叉项目YG2013MS59Supported by National Natural Science Foundation of China 81100824,Innovation Research Fund of Shanghai Municipal Education Commission 12YZ044 and Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University YG2013MS59.