Zhejiang Medical Science and Technology Project2018KY310;Key Projects of Zhejiang Provincial Major Medical and Health Science and Technology PlanWKJ-ZJ-1712;Zhejiang Medical and Health Science and Technology Project2015KYA036;Zhejiang Medical and Health Science and Technology Project 2017KY029浙江省医药卫生科技面上项目2018KY310;浙江省医药卫生重大科技计划省部共建重点项目WKJ-ZJ-1712;浙江省医药卫生科技计划项目2015KYA036;浙江省医药卫生科技计划项目2017KY029