Preorganized cationic pillararene as efficient carriers for intracellularly delivering native proteins
As a novel clinical treatment technology,intracellular protein delivery has attracted great attention because of its ability to specifically manipulate cellular functions and accurately treat dis-eases by acting on intracellular targets.Although therapeutic pro-teins have shown great promise in the pharmaceutical industry,most of them have membrane impermeability and mainly act on extracellular targets,which limits the clinical application of thera-peutic proteins to a certain extent.Therefore,in order to promote the clinical application of therapeutic proteins and protein-based biotechnology,the invention of excellent intracellular protein de-livery technologies and carriers has become one of the current re-search hotpots.With the development of supramolecular chem-istry,utilizing macrocyclic molecules to mimic cell-penetrating peptide has gradually attracted great attentions.
native、carriers、cationic、delivering、efficient、intracellularly、pillararene、preorganized、proteins
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TP311.13;TP393.02;TN929.5
2023-06-07（万方平台首次上网日期，不代表论文的发表时间）
共2页
1-2
