2019 highlights of the structural revision of natural product via total synthesis
For over a century,chemical synthesis has played an essential role in the structural assignment of natural products.With the development of characterization instrumentation and methods[1],such as nuclear magnetic resonance(NMR),high-resolution mass spectrometry,X-ray crystallography etc.,natural product chemists view synthetic chemistry more as an assistive technology and less as a core competence.Contrary to this opinion,the development of synthetic chemistry will continue to be critical in the structural evaluation of natural products.Two comprehensive reviews on natural products with revised structures have already been published[2,3].Many natural products had their structures reassigned,in particular their stereochemical configurations,by total synthesis in 2019[4-13].This paper covers some selected examples.
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We thank the Australian Research Council Discovery Grants Scheme and the University of Melbourne Research Grants Support Scheme for funding
2021-06-29（万方平台首次上网日期，不代表论文的发表时间）
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595-601
