This study was supported by grants from National Natural Science Foundation of China to Qingling WANG81101493;National Natural Science Foundation of China to Haijun BAO81302612;Specialized Research Fund for Doctor of Xuzhou Medical College to Haiying LI No.D2014003.本研究受国家自然科学基金项目81101493;国家自然科学基金项目81302612;徐州医学院人才项目启动基金D2014003