天津市科委课题11JCYBJC11300;国家自然科学基金81372517;国家科技重大专项2013ZX09303001;院级课题1317;CSCO-先声抗肿瘤血管靶向治疗科研基金No.Y-S2014-011资助hTis study was supported by the grants from Tianjin Science & Technology Council to Kai LI11JCYBJC11300;National Natural Science Foundation of China to Kai LI81372517;National Key S&T Special Projects to Kai LI2013ZX09303001;Research Projects to Cuicui ZHANG1317;to Jing WANGY-S2014-011