10.3321/j.issn:1000-4718.2005.06.048
钙激活的氯通道与哮喘气道粘液过度分泌
Ca2+-activated chloride channels (CaCC, CLCA) are a new family of chloride channels discovered recently, which are related to Ca2+-sensitive chloride ions transport, and there were several members identified currently in different biologic bodies. New studies have shown that its member gob-5 in murine (its human counterpart is CaCC1) plays a pivotal role in airway goblet cell metaplasia, mucus overproduction, MUC5AC gene expression as well as airway hyperresponsiveness (AHR) in asthma, and is a key molecule in the induction of murine asthma and an asthma-related gene. Inhibition of their function and/or their signaling pathway may therefore provide a new therapeutic strategy for asthma.
钙、氯通道、粘蛋白类、粘液、哮喘
21
R363(病理学)
2005-08-04(万方平台首次上网日期,不代表论文的发表时间)
共4页
1239-1241,1245