Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
Dear Editor,
The severe fever with thrombocytopenia syndrome virus(SFTSV)is an emerging tick-borne pathogen belonging to the genus Bandavirus,family Phenuiviridae,which causes high fatality rates ranging from 12％to 30％(Kim et al.,2013).In the absence of efficacious drugs and vac-cines,therapies for SFTS are performed mostly according to the clinical manifestations accompanied by supportive treatment.The SFTSV poly-merase protein(SFTSV-L),encoded by its L segment,plays a critical role in genomic replication and transcription.Similar to other single negative-sense RNA viruses(sNSRVs),such as the influenza A virus(FluA)and the La Crosse virus(LASV),the SFTSV-L can be divided into three main functional regions,with the RNA-dependent RNA polymerase(RdRp)region flanked by the endonuclease region at the N-terminus and the cap-binding functional region at the C-terminus(Sanchez and de la Torre,2005;Pflug et al.,2014;Vogel et al.,2020a;Wang et al.,2020).
mechanism、insights、protein、virus、with、conserved、domains、fever、functional、hrombocytopenia
37
G632.3;G423.3;TH13
2023-05-16（万方平台首次上网日期，不代表论文的发表时间）
共4页
946-949
