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Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells

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Dear Editor, Influenza B viruses(IBVs)have circulated among humans for more than 80 years.Seasonal influenza virus epidemics caused by two IBV lines(Victoria and Yamagata)and influenza A virus have considerable effects on public health globally and result in approximately 290,000-650,000 annual influenza-attributed deaths(Caini et al.,2015;Pan et al.,2015).Currently,the most effective countermeasures against influenza B virus infections are influenza virus vaccines(Subbarao and Matsuoka,2013).However,these vaccines have limited efficacy because only strain-matched humoral immune responses are induced,while the globular head domain of viral hemagglutinin(HA)continues to evolve rapidly.In addition,few anti-influenza drugs are available,and the treatment window for administering the available drugs is small(Subbarao and Matsuoka,2013;van de Sandt et al.,2015).A universal drug that targets both influenza B virus lineages remains a public health priority.Conferring passive immune protection using broadly neutral-izing antibodies(bnAbs)may be a promising alternative viral infection treatment(Wilson and Andrews,2012;Corti and Lanzavecchia,2013;Walker and Burton,2018).

development、cells、virus、activation、against、antibodies、cytidine、deaminase、functional、hybridoma

37

S;H31;TF806.1

2023-05-15(万方平台首次上网日期,不代表论文的发表时间)

共4页

619-622

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中国病毒学

1674-0769

42-1706/Q

37

2022,37(4)

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