Construction and verification of an infectious cDNA clone of coxsackievirus B5
Dear Editor,
Enteroviruses belonging to the family Picornaviridae are non-enveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses ge-nomes represent a single open reading frame flanked by 5'-and 3'-un-translated terminal regions(UTRs),constituting the basis for classifying enteroviruses into groups A-D(Zaoutis et al.,1998).Current research is primarily focused on highly prevalent pathogens,including enterovirus A71(EV-A71)and coxsackievirus A16(CV-A16)of group A(Duan et al.,2021).However,group B viruses are also responsible for a significant number of infections that often cause histopathological changes in the heart,brain,and pancreas.For instance,coxsackievirus B5(CV-B5)can induce aseptic meningitis,viral meningitis,acute flaccid paralysis,pancreatitis,and type I diabetes mellitus(Chen et al.,2020;Fran?ozo et al.,2019;Hy?ty et al.,2018).HFMD outbreaks caused by CV-B5 have been reported in China,Southeast Asia,and Europe.However,despite its clinical significance,little is known about its pathogenesis,and in-depth studies on the underlying mechanisms are urgently needed(Gao et al.,2018;Sciandra et al.,2020).
cdna、clone、construction、coxsackievirus、infectious、verification
37
Q78;R392;Q943.2
2022-09-14(万方平台首次上网日期,不代表论文的发表时间)
共3页
469-471