Link between dysregulated hypoxia signaling and aberrant methylation in clear cell renal cell carcinoma?

摘要：

Dysregulated pseudo-hypoxia (through its effects on cell survival,angiogenesis,metabolism,invasion) and epigenetic dysregulation ”through widespread suppression of tumor suppressor genes involved in cell cycle,apoptosis,adhesion,immune evasion,etc.(1)” are considered to be the two central driving pathogenic features in the progression of clear cell Renal Cell Carcinoma (ccRCC) (2,3).These two features also play a significant role in mediating the chemoresistance of radioresistance of ccRCC.The finding of increased DNA methyltransferase 1 (DNMT1) expression in ccRCC by Li et al.(4) provides one mechanistic reason for the previously reported genome wide aberrant methylation seen in ccRCC,leading to the suppression of various important tumor suppressor genes (3,5).Strikingly,this finding may also establish a link between the driver hypoxia inducible factor (HIF) pathway and aberrant methylation seen in von Hippel-Lindau (VHL) defective ccRCC.

机标关键词：tumor suppressor genes、DNA methyltransferase、Renal Cell Carcinoma、cell survival、cell cycle

所属期刊栏目：29

分类号：R73;R3

在线出版日期：2017-09-15（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：166-167