Making cancer fat: reprogramming of lipid metabolism by CD147 in hepatocellular carcinoma

摘要：

Over the past few years,de novo lipogenesis has taken central stage in the field of cancer metabolism (1).Large amount of lipids is needed for synthesis of membranes,signaling molecules,lipoproteins,etc.to support rapidly growing tumor cells (2-4).Reports have shown that neoplastic tissues show aberrant activation of de novo lipogenesis and that inhibition of different enzymes within the fatty acid biosynthesis pathway can block cancer cell growth (2,5-9).Meanwhile,the importance of fatty acid oxidation (FAO) in cancer metabolism is being increasingly recognized.FAO is the catabolic process by which lipids are utilized to produce energy.Recent studies implicated that the key regulatory enzymes in FAO such as carnitine palmitoyltransferase 1 (CPT1) and peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) regulate cancer development (10,11).The underlying mechanisms for the regulation of de novo lipogenesis and FAO in cancers are,however,still incompletely understood.Thus,it would be of a high scientific and clinical interest to elucidate the lipid metabolism in cancer.

机标关键词：hepatocellular carcinoma、fatty acid oxidation、lipid metabolism、tumor cells、cell growth

所属期刊栏目：28

分类号：R3 ;R5

资助基金：the Basic Science Research Program through the National Research Foundation of Korea,which is funded by the Ministry of Education NRF-2011-0021830 to SW Ro

在线出版日期：2016-07-26（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：380-382