Improving cancer therapy by combining cell biological, physical,and molecular targeting strategies

摘要：

Successful cancer therapy depends on selective killing of tumor cells while sparing normal cells.Selectivity can be achieved through treatment strategies that target tumor cells.A recent report from the Li laboratory (1) describes an elegant strategy to selectively kill tumor cells by combining several targeting strategies based on cell biological,physical,and molecular (genetic) properties of tumor and normal cells that enhances tumor cell killing in vitro and in an in vivo tumor xenograft model.The idea of using a multiplex targeting approach is reminiscent of strategies in which several antibiotics are used to treat bacterial infections while minimizing the chance that rare antibiotic-resistant mutants will arise within a population.

机标关键词：tumor cells、bacterial infections、cancer therapy、in vitro

所属期刊栏目：25

分类号：R73;R45

资助基金：Research in the Nickoloff lab is supported by NIH grant R01 GM084020 and the Japan National Institute of Radiological Sciences International Open Laboratory Program

在线出版日期：2013-05-03（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：7-9