Expression of Gli1 in the hedgehog signaling pathway and breast cancer recurrence

摘要：

The hedgehog (Hh) signaling pathway plays an essential role in the embryonic development and homeostasis of diverse adult tissues,and its deregulation has been implicated in the tumorigenesis and metastasis of various malignancies including breast cancer.Aberrant activation of the Hh pathway includes the following mechanisms:(Ⅰ) Hh ligand-independent mechanism-Loss of function mutations in the Hh receptor Patched 1 (PTCH1) or gain of function mutations in the Smoothened (SMO) lead to constitutive activation of this pathway;(Ⅱ) Autocrine signaling-Hh ligand produced by tumor cells stimulates the Hh signaling in tumor cells;(Ⅲ) Paracrine signaling-tumor cell produced-Hh ligand activates stromal and endothelial cells that produce growth factors in microenvironment for supporting tumor growth and survival;and (Ⅳ) Reverse paracrine signaling-Hh ligand produced by stromal cells support tumor growth and survival.

机标关键词：breast cancer、tumor growth、tumor cells、embryonic development、endothelial cells、growth factors、stromal cells

所属期刊栏目：24

分类号：R73;R3

在线出版日期：2013-03-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：257-258