国家“十二五”科技重大专项基金资助项目2012ZX10001006;辽宁省教育厅重点实验室项目LZ2014038;中国医科大学附属第一医院科技基金项目FSFH1512;grants from the National Science and Technology Major Project of China2012ZX10001006;Basic Research Project of Key Laboratory of Education Department of Liaoning ProvinceLZ2014038;Technology Grants from the First Affiliated Hospital of China Medical UniversityFSFH1512