10.3321/j.issn:0513-4870.2009.02.014
Spectrophotometric determination of tranexamic acid using vanillin
A new spectrophotometric method has been examined for the determination of the tranexamic acid (TA)by derivatization with vanillin(VAN).The molar absorptivity of TA was calculated 25 160 L·mol-1·cm-1at λ max 354 nm and obeyed the Beer”s law within 0.5-2.5 μg·mL-1.The color reaction was highly stable and didnot show any change in absorbance up to 24 h.The method was applied for the analysis of TA from capsules,injections and tooth pastes.The amounts of TA found in capsules,injections and tooth pastes of various pharmaceutical companies were observed with 249.0-250.9 mg/capsule,249.3-250.7 mg/injection and 0.048%-0.049%in tooth pastes with relative standard deviation(RSD)0.2%-5.0%(n=3).
tranexamic acid、vanillin、spectrophotometry
44
R917(药物基础科学)
2009-04-03(万方平台首次上网日期,不代表论文的发表时间)
共6页
175-180