The Natural Science Foundation of Shandong ProvinceZR2015YL026;Qingdao Southern District Science and Technology Development Fund Project2018-4-030-YY;The Innovation Project of Shandong Academy of Medical Sciences 山东省自然科学基金ZR2015YL026;青岛市南区科技发展资金项目2018-4-030-YY;山东省医学科学院医药卫生科技创新工程