浙江省公益技术应用研究计划2015C37132;浙江省医药卫生科技项目省部共建重点项目2018273482;浙江省医药卫生科技计划2018235172;Experimental Animal Science Project of Science Technology Department of Zhejiang Province of China2015C37132;Medical Scientific Research Foundation of Zhejiang Province of China2018273482;Medical Scientific Research Foundation of Zhejiang Province of China2018235172