Project supported by the National Key Research and Development Program of the Ministry of Science and Technology ;the Natural Science Foundation of China ;CAS Strategic Pilot Science And Technology Special ;and the Program of Shanghai Academic Research Leader ;科技部国家重点研发计划No.2016YFA0202900、国家自然科学基金Nos.21725104.21690062.21821002、中国科学院先导专项No.XDB20000000;上海市优秀学术带头人计划