Transcriptomic profiling of tumor microenvironment reveals distinct immune subgroups of metastatic melanoma and its potential implications for immunotherapy
Agents that induce an immune response against tumors by altering the immunologic microenvironment have shown remarkable efficacy in various solid cancers,such as metastatic melanoma(Johnson and Sosman,2015;Luke et al.,2017).However,despite the high rate of response in advanced melanoma compared with other cancer types,most patients still succumb to the disease(Sharma et al.,2017;O'Donnell et al.,2019).Identifying potential mechanisms associated with treatment response or resistance would allow tailoring of appropriate immunotherapy for different pa-tient subgroups (Sia et al.,2017;Chen et ai.,2019;Zhang et al.,2020).To understand the molecular mechanisms underpinning its antitumor response and characterize the molecular features of the tu-mor microenvironment (TME) associated with immunotherapy responsiveness,we integrated the single-cell RNA-sequencing(scRNA-seq) dataset of melanoma samples and the transcriptomes of a patient cohort with 358 metastatic melanoma samples from The Cancer Genome Atlas (TCGA) database to identify the novel im-mune molecular subgroups.
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2021-09-03(万方平台首次上网日期,不代表论文的发表时间)
共3页
426-428