Whole-exome sequencing reveals genetic underpinnings of salivary adenoid cystic carcinoma in the Chinese population
Salivary gland carcinomas (SGCs) are rare malignancies that remain poorly understood owing to their low incidence (Matsuba et al., 1986b; Liu et al., 2012). As per GLOBOCAN 2018, 52,800 new cancers arising from salivary glands were estimated to be diag-nosed across the world that year. Because of their high propensity to invade local and perineural structures, SGCs impose significant threat of local recurrence and distant metastasis to patients, leading to high mortality (Matsuba et al., 1986b). Among SGCs, adenoid cystic carcinoma (ACC) is one of the major types of cancer arising from the submandibular and minor salivary glands, characterized by its short-term therapeutic outcomes from treatment and unpre-dictable long-term metastatic tendencies (Matsuba et al., 1986a).The incidence of SGC in China is estimated to be around 0.45％,with 6191 new cases diagnosed in 2015 (Chen et al., 2016), and inci-dence of ACC is even lower, accounting for 26.92％ of SGC (Lyu et al.,2019). Therefore, this tumor can be classified as a rare tumor as per the definition established by the European Society for Medical Oncology (ESMO) (incidence of ≤6 per 100,000; Gatta et al.,2010). The low incidence of ACC in the salivary glands has thwarted the exploration of molecular underpinnings of this enigmatic ma-lignancy (Liu et al., 2012; Ho et al., 2013). It is also worth noting that to date, all these investigations have been performed in Cauca-sian populations; whether similar mutational patterns are observed in Asia is unclear.
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This study was supported by the Chinese Academy of Medical Sciences grant No. 2019XK320068
2021-02-25（万方平台首次上网日期，不代表论文的发表时间）
共5页
397-401
