Mitochondrial replacement techniques or therapies (MRTs) to improve embryo development and to prevent mitochondrial disease transmission
The mitochondrion which contains its own double-stranded circular DNA is a semi-independent organelle that plays critical roles in cell activity.Mitochondrial DNA (mtDNA) is maternally inherited through several mechanisms that have been proposed (Luo et al.,2013) and,if mitochondrial mutations are inherited to the offspring,it is possible to cause mitochondrial diseases such as neuropathy,cardiomyopathy,myopathy,and liver failure.In patients with mtDNA diseases,either all copies of mtDNA are mutated (homoplasmy),or a large proportion of mutated mtDNA co-exists with wild-type mtDNA (heteroplasmy) (DiMauro and Schon,2008).Clinically,most maternally inherited mitochondrial diseases are caused by heteroplasmy,and only a high proportion (usually greater than 60％) of mutated mtDNA in affected tissues will cause diseases (Taylor and Turnbull,2005).Until recently,limited success has been achieved in developing effective treatment for mtDNA diseases.
mitochondrial disease、liver failure
44
R74;R39
2017-11-07（万方平台首次上网日期，不代表论文的发表时间）
共4页
371-374
