Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells
The estrogen receptor (ER)-related factor (ERRF) was previously reported as a novel modulator of breast cancer (Su et al.,2012).Its expression was upregulated in breast cancer,and increased ERRF expression was significantly associated with ER and/or progesterone receptor (PR) positivity and human epidermal growth factor receptor 2 (HER2) negativity (Suet al.,2012).In addition,ERRF was necessary for ER-positive breast cancer cells to form tumors in nude mice (Su et al.,2012).Unexpectedly,higher ERRF protein expression was significantly associated with better breast cancer patient survival,particularly those with the luminal A subtype tumors (ER-and/or PR-positive and HER2-negative) (Suet al.,2012).While these findings suggest that ERRF plays a role in the development of breast cancer in the context of estrogen-ER signaling,how ERRF functions is unknown.The correlation between ERRF upregulation and ER-and/or PR-positivity suggests that ERRF could be a mediator of ER”s oncogenic function,but the association of ERRF upregulation with better patient survival suggests a different scenario.ERRF could be activated by an unknown mechanism to transform ER-positive breast epithelial cells,leading to ER+ breast cancer.
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2016-11-03（万方平台首次上网日期，不代表论文的发表时间）
565-567
