Derivation of Non-Integration Induced Pluripotent Stem Cells from Fibroblast of Severe Deafness Patients with GJB2 Mutation
In all the connexin-associated human diseases,deafness is one of the most important diseases with high frequency.The mutations of GJB2 (gap junction protein β2,also called connexin 26,Cx26) gene link with nonsyndromic or syndromic sensorineural hearing loss and were shown to account for a large proportion of congenital deaf cases in many studied populations (del Castillo and del Castillo,2011).For example,the 235delC mutation in GJB2 shows the frequency of approximately 1％ and is the most frequent mutation in East Asian population (Yan et al.,2003).Many efforts have been put to study the function of Gjb2 gene in both mouse model and human.
42
This work was supported by grants from the National Key Basic Research Programs of China Nos.2012CB966600 and 2012CB967900,the National Natural Science Foundation Project No.31371506 and the 12th Five-Year National Key Technologies R&D Program No.2012BAI12B00.
2015-10-08（万方平台首次上网日期，不代表论文的发表时间）
455-458
