国家自然科学基金81800448;广州科技创新委员会201707010369;广东省医学科学研究基金A2017409;广州卫生和计划生育委员会20171a011258;National Natural Science Foundation of China81800448;Guangzhou Scientific & Technological Innovation Committee201707010369;Medical Scientific Research Foundation of Guangdong ProvinceA2017409;Guangzhou Municipal Health & Family Planning Commission20171a011258