国家自然科学基金81700569;天津市自然科学基金17JCYBJC28000;天津市卫生计生委科技攻关项目16KG101;天津市卫生计生委中医中西医结合科研课题2017056Natural Science Foundation of China81700569;Natural Science Foundation of Tianjin17JCYBJC28000;Science and Technology Foundation of Tianjin Health Bureau16KG101;Integrated Western and Chinese Science Foundation of Tianjin Health Bureau2017056