国家自然科学基金81401763;上海市卫生计生委科研项目20144Y0176;上海市科学技术委员会科研项目12DZ2295006;上海交通大学医学院“985”计划基金YBKL2013008National Natural Science Foundation of China81401763;Health & Family Planning Committee of Shanghai Science Foundation20144Y0176;Shanghai Science & Technology Committee12DZ2295006;985 Project Fund from Shanghai Jiao Tong University School of MedicineYBKL2013008