国家自然科学基金81541100;天津市卫生计生委攻关项目14KG129;北京市医院管理局临床医学发展专项经费资助XMLX201603 National Nature Science Foundation of China81541100;Tianjin Health Bureau Key Projects14KG129;Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding SupportXMLX201603