国家自然科学基金资助项目30670576;国家自然科学基金资助项目81271519;北京市自然科学基金资助项目4122018;首都医科大学自然科学基金资助项目2013ZR12;This study was supported by National Natural Science Foundation of China30670576,81271519;Beijing Natural Science Foundation4122018;Capital Medical University Natural Science Foundation2013ZR12