Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence
Dear Editor,
Pseudomonas aeruginosa is a ubiquitous Gram-negative oppor-tunistic bacterium that notoriously causes infections with a high mortality rate in hospitalized patients,especially those with compromised immune systems.1 P.aeruginosa can cause acute infections that are typically associated with the cytotoxins secreted by the type Ⅲ secretion system(T3SS),2 as well as chronic persistence that relies on type Ⅵ secretion system(T6SS)and biofilm formation,including those in cystic fibrosis patients.3 An intercellular communication network based on cell density,quorum sensing(QS),regulates numerous gene expressions including those related to both acute and chronic virulence of P.aeruginosa.4 The global regulatory protein of the repressor of secondary metabolites(Rsm)system in bacteria,RsmA,is found to predominantly regulate these virulence entities in P.aeruginosa by modulating related gene expressions at transcriptional and posttranscriptional levels.5
pseudomonas、virulence、basis、srna、rsmz、aeruginosa、regulation、structural
33
S;Q936;X172
2023-05-29（万方平台首次上网日期，不代表论文的发表时间）
共3页
328-330
