Transcription initiation by the ERRs:no ligand but two activation pathways
Estrogen-related receptors(ERRα,β and y)are orphan nuclear receptors that control the transcription of genes involved in the production of cellular energy in response to develop-mental and physiological cues.Nakadai and colleagues now demonstrate that ERR isoforms utilize two complementary mechanisms to induce distinct gene programs:one depen-dent on a direct interaction with the p52 subunit of the initiation factor TFIIH,the other contingent on the presence of cell-specific coactivators to recruit p300 and Mediator to ERR-bound promoters.
pathways、ligand、activation、errs、initiation、transcription
33
G250.76;R734.2;O643
2023-05-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
269-270