Life mimics art
Ichikawa et al.have discovered that C-terminal cyclic imides imitate the chemical motif of molecular glue degrader thalidomide and act as a naturally occurring degron of the E3 ligase cereblon.
Thalidomide and its derivatives lenalidomide and pomalido-mide are immunomodulatory drugs(IMiDs)used in the frontline treatment of hematological malignancies.1 These IMiDs—parti-cularly the bestselling drug lenalidomide(~$12.8 billion in 2021)—are clinically effective against multiple myeloma,myelo-dysplastic syndrome,lymphoma,and follicular lymphoma.How-ever,half a century ago,thalidomide treatment resulted in severe birth defects in thousands of babies.2 By 2010,scientists discovered that thalidomide curbs limb development in zebrafish and chickens through its interaction with cereblon,3 a evolution-ally conserved protein named after its presumed role in cerebral development4 and whose dysfunction is associated with mild intellectual disability.5
mimics、life
33
R318;R782.4;R683
2023-05-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
267-268