A type Ⅲ-E CRISPR Craspase exhibiting RNase and protease activities

摘要：

Type Ⅲ-E CRISPR-Cas effector gRAMP/Cas7-11 is a RNA-guided RNA endonuclease associated with a putative caspase-like protease TRP-CHAT/Csx29,which targets endogenous protein substrate Csx30.In a recent paper published in Science,the Ailong Ke lab has captured cryo-EM snapshots of the nuclease-protease complex Craspase in both resting and different functional states;this paper together with four other related studies have elucidated the molecular mechanisms of both target RNA cleavage and RNA-mediated allosteric regulation of protease catalytic activity,thereby highlighting RNA-dependent protease-based programmed cell death.

机标关键词：crispr、rnase、activities、craspase、exhibiting、protease、type

所属期刊栏目：32

分类号：Q78;Q943;R392.1

在线出版日期：2023-02-10（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：1044-1046