Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors

摘要：

In a recent study published in Nature,Kalbasi et al.demonstrate that engineering T cells to express a chimeric orthogonal IL-2 receptor,where the intracellular domain(ICD)of the receptor was replaced with the IL-9 receptor ICD,mitigated negative impacts of IL-2 administration and also drove signaling through STAT1,STAT3 and STAT5 to promote anti-tumor function and T cell stemness.

机标关键词：through、function、cell、chimeric、cytokine、engineered、fine-tuning、orthogonal、receptors

所属期刊栏目：32

分类号：H3.1;TP391;TN919

在线出版日期：2023-01-13（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：967-968