Promoting T and NK cell attack:preserving tumor MICA/B by vaccines

摘要：

The activating receptor NKG2D,first discovered in the late 1990's,participates in the immune surveillance of cytotoxic lymphocytes through recognition of the stress-induced ligands MICA/B on the surface of malignant cells.Recently,a study by Badrinath et al.in Nature described a vaccine targeting approach that prevents proteolytic cleavage of MICA/B,leading to enhanced immune infiltration and anti-tumor responses highlighting the importance of NKG2D interactions on both natural killer cells and T cells.

机标关键词：tumor、mica、cell、attack、preserving、promoting、vaccines

所属期刊栏目：32

分类号：R73;R94;TP332

在线出版日期：2023-01-13（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：961-962