Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine
Dear Editor,
Voltage-gated calcium(Cav)channels regulate a broad range of physiological processes,such as muscle contraction,synaptic signal transduction,and hormone secretion.1 Cav1.3 channels belong to the L-type(L for long-lasting current)Cav subfamily(LTCC)and display diverse tissue distributions in brain,ear,heart,and endocrine organs.2 Of note,Cav1.3 channels are predomi-nantly expressed in cochlea inner hair cells,whose normal development and synaptic transmission are crucial for proper auditory function.3
motion、channel、human、basis、blockade、calcium、cinnarizine、drug、pore、sickness
32
TP393.02;Q244;TH122
2022-11-10(万方平台首次上网日期,不代表论文的发表时间)
共3页
946-948