AHI1:linking depression and impaired antiviral immune response
AHI1 is a neurodevelopmental gene,and its expression deficiency was found to correlate with altered stress responses and depressive behaviors in mice.In a recent paper of Cell Research,Zhang et al.show that AHI1 reduction is also associated with attenuated antiviral innate immunity,providing an important linker between depression and reduced antiviral immune response.
The Abelson helper integration site 1(AHI1)gene encodes a multifaceted protein that contains 7 WD40 repeats,an SH3 domain and numerous SH3-binding sites,and is involved in brain development.Nonsense or frameshift mutations in AHI1 lead to Joubert syndrome,a recessive neurodevelopmental disorder characterized by multi-system abnormalities including motor deficits,cognitive impairment,low muscle tone,and abnormal eye movements.1 Genetic studies revealed that AHI1 is also a susceptibility gene for schizophrenia2 and autism,3 two important neuropsychiatric disorders associated with abnormal early brain development and depressive behaviors.The potential role of AHI1 in depression was further supported by the findings that Ahi1-deficient mice display depressive phenotypes4 and resilience to stress.5 Consistently,Ahi1 was found to participate in maintaining the level of tyrosine kinase receptor B(TrkB)in the mouse brain4 which is critical for neuronal differentiation and brain develop-ment.However,since AHI1's expression is widespread in the brain and peripheral tissues,whether AHI1 in non-neuronal cells also plays a role in depression-associated phenotypes remains elusive.
depression、antiviral、immune、impaired、linking、response
32
R395.6;R749.79;P3
2022-11-10（万方平台首次上网日期，不代表论文的发表时间）
共2页
869-870
