Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor
Dear Editor,
The thyrotropin-releasing hormone(TRH)is the initial hormone of the hypothalamo-pituitary-thyroid axis(HPT),a signaling cascade required for metabolic homeostasis and development in vertebrates.TRH is a tripeptide hormone(pGlu-His-Pro-NH2)that is synthesized in the hypothalamus and activates thyrotropin-releasing hormone receptor(TRHR),a member of class A G protein-coupled receptor(GPCR).Activated TRHR couples to Gq and activates the phospha-tidylinositol(IP3)-calcium-protein kinase C(PKC)pathway1 that ultimately leads to upregulation of thyroid hormones.
insights、receptor、ligand、human、activation、binding、hormone、into、releasing、structural
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R736.4;G423.3;G632.3
2022-10-21(万方平台首次上网日期,不代表论文的发表时间)
共3页
855-857