R-2-HG assists IDH1-mutant solid tumors by promoting angiogenesis

摘要：

Mutations in isocitrate dehydrogenase lead to the elevated production of the oncometabolite R-2-hydroxyglutarate(R-2-HG),which,albeit insufficient for malignant transformation,exerts intrinsic and paracrine effects that promote tumor propagation and progression.In a recent paper of Cell Research,Wang and colleagues describe a novel extrinsic proangiogenic function of tumor-secreted R-2-HG that,upon uptake by the sodium-dependent glutamate transporter SLC1A1 in tumor endothelial cells,promotes mitochondrial respiration and ATP production leading to enhanced tip cell activity and endothelial cell migration.

机标关键词：solid、angiogenesis、assists、idh1-mutant、promoting、tumors

所属期刊栏目：32

分类号：TP391;TF062;TG50

在线出版日期：2022-10-21（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：795-796