Shaping the sinuses:a novel Krt14+Ctsk+cell lineage driving regenerative bone formation
The specific skeletal cell types involved in bone formation around the sinus remain unclear.In a recent paper published in Cell Research,Weng et al.identify a novel lineage with mixed epithelial and osteoblast features that mediates bone formation in regenerative procedures involving the maxillary sinus.
The past few years have seen a revolution in defining the cell types forming the skeleton.The field has moved from defining cells based on morphology towards a combination of using cre-based genetic markers to label specific lineages and cell surface markers to define discrete cell types within those lineages.This work has led not only to increasingly precise definitions of skeletal stem cells,1-3 but moreover to an understanding that bone is not formed by a single stem/progenitor cell,but rather through the combined actions of several distinct lineages of stem and progenitor cell types,each with distinct anatomic location and physiologic function.
novel、bone、driving、formation、krt14+ctsk+cell、lineage、regenerative、shaping、sinuses
32
H13;TN919;O
2022-10-21（万方平台首次上网日期，不代表论文的发表时间）
共2页
791-792
