Basophils orchestrate kidney fibrosis
Basophils,though representing a minor population of leukocytes,have diverse roles in various pathophysiologies.A recent report provides an additional evidence on the pathogenic role of basophils in promoting kidney fibrosis by secreting IL-6 and promoting the Th17 cell differentiation.
Basophils are rare granulocytes that participate in T helper(Th)type 2 immunity,principally through the secretion of interleukins IL-4 and IL-13.Besides their role in the defense against helminth infections,basophils play a major role in the pathogenesis of various allergic inflammatory diseases,autoimmune diseases,and cancer.1 Basophils express a diverse array of receptors,and hence could sense signals from various sources including cytokines,toll-like receptor agonists,and allergens,and subsequently undergo rapid activation and release inflammatory mediators.In addition to IL-4 and IL-13,basophils produce histamine,prostaglandins,leukotrienes,IL-6 and chemokines in response to the stimuli.All these inflammatory mediators are potential contributors of basophil-mediated pathogenesis.
fibrosis、kidney、basophils、orchestrate
32
R692.3;R692;S
2022-08-12（万方平台首次上网日期，不代表论文的发表时间）
共2页
713-714
