A BAF-fling connection to RIPK1

摘要：

RIPK1 is a multifaceted kinase with roles in diverse cellular processes,including cell death,innate immunity,and inflam-matory signaling.RIPK1 can also facilitate inflammatory diseases,like amyotrophic lateral sclerosis(ALS)and Alzhei-mer's disease(AD),independent of its cell death functions;in a recent Cell Research paper,Li et al.show that this results from RIPK1 acting as a transcriptional coregulator,forming a nuclear complex with the BAF complex through direct interactions with BRG1 and SMARCC2,mediating phosphor-ylation of SMARCC2,and promoting chromatin remodeling and transcription of proinflammatory genes.

机标关键词：connection、ripk1、baf-fling

所属期刊栏目：32

分类号：TP311.52;R733.71;R914

在线出版日期：2022-08-12（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：709-710