Maternally loaded RNAs:no time to die
Upon fertilization,the animal genome is often inactive and development is driven by proteins and transcripts that are stored in the egg during oogenesis.In a recent Cell Research paper,Shi et al.show that the RNA helicase Ddx3xb facilitates the translation of stored transcripts in zebrafish embryos by a phase separation-dependent process.
The development of animal embryos is initially directed by maternally provided proteins and RNAs.Developmental control is gradually handed over to the embryo during the maternal-to-zygotic transition,when the zygotic genome is activated.1 To ensure a successful change from the maternal to the zygotic gene expression program,maternal transcripts are degraded during this transition.The changes in gene expression are precisely controlled and highly interconnected(Fig.1).In zebrafish,for example,the translation of maternally loaded RNAs is required to activate zygotic transcription,while the zygotic transcription of a micro-RNA is required to initiate the degradation of many maternal transcripts.This raises an interesting conundrum:maternally loaded RNAs need to be translated before they are degraded.
rnas、time、loaded、maternally
32
R322.81;R741;Q522
2022-08-12（万方平台首次上网日期，不代表论文的发表时间）
共2页
707-708
