Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo
Dear Editor,
The outbreak of coronavirus disease 2019(COVID-19)has resulted in a severe global pandemic that has lasted for more than two years.1 Several vaccines were developed at an unprecedented speed to protect billions of people.2 Many monoclonal antibodies have also been discovered,several of which are in the clinical stages.3 However,limited vaccine availability and vaccine hesi-tancy compromise the impact of vaccines.The continuous evolution of SARS-CoV-2 has also resulted in many variants that can escape immunity,reducing the effects of vaccines and antibodies.4 With more than 30 mutations in the spike protein,the Omicron variant escapes the majority of existing antibodies and extensively evades vaccine-induced immunity.56 Thus,therapeu-tics that are broadly effective against current and future emerging SARS-CoV-2 variants are still highly desirable.
sars-cov-2、delta、vivo、against、efficacy、enhanced、exhibits、omicron、potent、prophylactic
32
R511;R373.1;R978.7
2022-08-11（万方平台首次上网日期，不代表论文的发表时间）
共4页
589-592
