Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders

摘要：

Dear Editor,
Protein amyloid aggregation is a histological hallmark of neurodegenerative diseases(NDs).1,2 In synucleinopathies includ-ing Parkinson's disease(PD),Parkinson's disease dementia(PDD),dementia with Lewy body and multiple system atrophy,α-synuclein(α-syn)is commonly characterized to form amyloid aggregates presenting distinct pathological activities in diseased brains.3,4 Structural characterization of a-syn amyloid fibrils formed in different diseases could provide mechanistic under-standing of heterogeneous a-syn pathologies.

机标关键词：parkinson、patient、normal、with、amyloid、dementia、disease、elders、fibrillation、generic

所属期刊栏目：32

分类号：R3;R77;G23

在线出版日期：2022-08-11（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：585-588